EC 1.3.1.48 - 15-oxoprostaglandin 13-reductase

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IntEnz Enzyme Nomenclature
EC 1.3.1.48

Names

Accepted name:
15-oxoprostaglandin 13-reductase
Other names:
15-ketoprostaglandin Δ13-reductase
15-oxo-Δ13-prostaglandin reductase
Δ13-15-ketoprostaglandin reductase
prostaglandin 13-reductase
prostaglandin Δ13-reductase
(5Z)-(15S)-11α-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Δ13-oxidoreductase
(5Z)-11α-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Δ13-oxidoreductase
Systematic name:
11α-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Δ13-oxidoreductase

Reactions

Comments:

Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. The enzyme from placenta is specific for NAD+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0036132 , GO:0047522
CAS Registry Number: 57406-74-3
UniProtKB/Swiss-Prot: (15) [show] [UniProt]

References

  1. Hansen, H.S.
    Purification and assay of 15-ketoprostaglandin Δ13-reductase from bovine lung.
    Methods Enzymol. 86: 156-163 (1982). [PMID: 6290839]
  2. Jarabak, J.
    Isolation and properties of a 15-ketoprostaglandin Δ13-reductase from human placenta.
    Methods Enzymol. 86: 163-167 (1982). [PMID: 7132753]

[EC 1.3.1.48 created 1990, modified 2014]