EC 1.3.1.21 - 7-dehydrocholesterol reductase

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IntEnz Enzyme Nomenclature
EC 1.3.1.21

Names

Accepted name:
7-dehydrocholesterol reductase
Other names:
sterol Δ7-reductase
7-DHC reductase
7-dehydrocholesterol dehydrogenase/cholesterol oxidase
Δ7-sterol reductase
DHCR7 (gene name)
Systematic name:
cholesterol:NADP+ Δ7-oxidoreductase

Reaction

Comments:

The enzyme is part of the cholesterol biosynthesis pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047598
CAS Registry Number: 9080-21-1
UniProtKB/Swiss-Prot:

References

  1. Dempsey, M.E., Seaton, J.D., Schroepfer, G.J., Jr. and Trockman, R.W.
    The intermediary role of Δ5,7-cholestadien-3β-ol in cholesterol biosynthesis.
    J. Biol. Chem. 239: 1381-1387 (1964). [PMID: 14189869]
  2. Moebius, F. F., Fitzky, B. U., Lee, J. N., Paik, Y. K., Glossmann, H.
    Molecular cloning and expression of the human delta7-sterol reductase.
    Proc. Natl. Acad. Sci. U.S.A. 95: 1899-1902 (1998). [PMID: 9465114]

[EC 1.3.1.21 created 1972, modified 2013]