EC 1.3.1.2 - Dihydropyrimidine dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature
EC 1.3.1.2

Names

Accepted name:
dihydropyrimidine dehydrogenase (NADP+)
Other names:
4,5-dihydrothymine: oxidoreductase
DHPDH
DHU dehydrogenase
DPD
dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)
dihydrothymine dehydrogenase
dihydrouracil dehydrogenase (NADP)
hydropyrimidine dehydrogenase
Systematic name:
5,6-dihydrouracil:NADP+ 5-oxidoreductase

Reaction

Comments:

Also acts on dihydrothymine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0017113
CAS Registry Number: 9029-01-0
UniProtKB/Swiss-Prot: (11) [show] [UniProt]

References

  1. Fritzson, P.
    Properties and assay of dihydrouracil dehydrogenase of rat liver.
    J. Biol. Chem. 235: 719-725 (1960). [PMID: 13825299]
  2. Shiotani, T. and Weber, G.
    Purification and properties of dihydrothymine dehydrogenase from rat liver.
    J. Biol. Chem. 256: 219-224 (1981). [PMID: 7451435]

[EC 1.3.1.2 created 1961, modified 1986]