EC 1.2.99.2 - Carbon-monoxide dehydrogenase (acceptor)

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IntEnz Enzyme Nomenclature
EC 1.2.99.2

Names

Accepted name:
carbon-monoxide dehydrogenase (acceptor)
Other names:
anaerobic carbon monoxide dehydrogenase
carbon monoxide oxygenase
carbon-monoxide dehydrogenase
carbon-monoxide:(acceptor) oxidoreductase
Systematic name:
carbon-monoxide:acceptor oxidoreductase

Reaction

Cofactors

Comments:

Contains a [Ni3Fe-4S] cluster and [4Fe-4S] clusters. It uses many electron acceptors, including ferredoxin, methyl viologen and benzyl viologen and flavins, but not pyridine nucleotides. Forms part of a membrane-bound multienzyme complex with EC 1.12.99.6, hydrogenase (acceptor), which catalyses the overall reaction: CO + H2O = CO2 + H2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018492
CAS Registry Number: 64972-88-9

References

  1. Bonam, D. and Ludden, P.W.
    Purification and characterization of carbon monoxide dehydrogenase, a nickel, zinc, iron-sulfur protein, from Rhodospirillum rubrum.
    J. Biol. Chem. 262: 2980-2987 (1987). [PMID: 3029096]
  2. Diekert, G. and Ritter, M.
    Purification of the nickel protein carbon monoxide dehydrogenase of Clostridium thermoaceticum.
    FEBS Lett. 151: 41-44 (1983). [PMID: 6687458]
  3. Drennan, C.L., Heo, J., Sintchak, M.D., Schreiter, E. and Ludden, P.W.
    Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase.
    Proc. Natl. Acad. Sci. USA 98: 11973-11978 (2001). [PMID: 11593006]
  4. Dobbek, H., Svetlitchnyi, V., Gremer, L., Huber, R. and Meyer, O.
    Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster.
    Science 293: 1281-1285 (2001). [PMID: 11509720]

[EC 1.2.99.2 created 1982, modified 1990, modified 2003]