EC 1.2.3.7 - Indole-3-acetaldehyde oxidase

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IntEnz Enzyme Nomenclature
EC 1.2.3.7

Names

Accepted name:
indole-3-acetaldehyde oxidase
Other names:
indoleacetaldehyde oxidase
IAA oxidase
IAAld oxidase
AO1
indole-3-acetaldehyde:oxygen oxidoreductase
Systematic name:
(indol-3-yl)acetaldehyde:oxygen oxidoreductase

Reaction

Cofactors

Comments:

A hemoprotein. This enzyme is an isoform of aldehyde oxidase (EC 1.2.3.1). It has a preference for aldehydes having an indole-ring structure as substrate [6,7]. It may play a role in plant hormone biosynthesis as its activity is higher in the auxin-overproducing mutant, super-root1, than in wild-type Arabidopsis thaliana [7]. While (indol-3-yl)acetaldehyde is the preferred substrate, it also oxidizes indole-3-carbaldehyde and acetaldehyde, but more slowly. The enzyme from maize contains FAD, iron and molybdenum [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050302
CAS Registry Number: 66082-22-2
UniProtKB/Swiss-Prot:

References

  1. Bower, P.J., Brown, H.M. and Purves, W.K.
    Cucumber seedling indoleacetaldehyde oxidase.
    Plant Physiol. 61: 107-110 (1978).
  2. Miyata, S., Suzuki, Y., Kamisaka, S. and Masuda, Y.
    Indole-3-acetaldehyde oxidase of pea-seedlings.
    Physiol. Plant. 51: 402-406 (1981).
  3. Rajagopal, R.
    Metabolism of indole-3-acetaldehyde. III. Some characteristics of the aldehyde oxidase of Avena coleoptiles.
    Physiol. Plant. 24: 272-281 (1971).
  4. Koshiba, T., Saito, E., Ono, N., Yamamoto, N. and Sato, M.
    Purification and properties of flavin- and molybdenum-containing aldehyde oxidase from coleoptiles of maize.
    Plant Physiol. 110: 781-789 (1996). [PMID: 12226218]
  5. Koshiba, T., Matsuyama, H.
    An in vitro system of indole-3-acetic acid formation from tryptophan in maize (Zea mays) coleoptile extracts.
    Plant Physiol. 102: 1319-1324 (1993). [PMID: 12231908]
  6. Sekimoto, H., Seo, M., Kawakami, N., Komano, T., Desloire, S., Liotenberg, S., Marion-Poll, A., Caboche, M., Kamiya, Y. and Koshiba, T.
    Molecular cloning and characterization of aldehyde oxidases in Arabidopsis thaliana.
    Plant Cell Physiol. 39: 433-442 (1998). [PMID: 9615466]
  7. Seo, M., Akaba, S., Oritani, T., Delarue, M., Bellini, C., Caboche, M. and Koshiba, T.
    Higher activity of an aldehyde oxidase in the auxin-overproducing superroot1 mutant of Arabidopsis thaliana.
    Plant Physiol. 116: 687-693 (1998). [PMID: 9489015]

[EC 1.2.3.7 created 1984, modified 2004, modified 2006]