EC 1.2.1.72 - Erythrose-4-phosphate dehydrogenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.2.1.72

Names

Accepted name:
erythrose-4-phosphate dehydrogenase
Other names:
erythrose 4-phosphate dehydrogenase
E4PDH
GapB
Epd dehydrogenase
E4P dehydrogenase
Systematic name:
D-erythrose 4-phosphate:NAD+ oxidoreductase

Reaction

Comments:

This enzyme was originally thought to be a glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12), but this has since been disproved, as glyceraldehyde 3-phosphate is not a substrate [1,2]. Forms part of the pyridoxal-5'-phosphate coenzyme biosynthesis pathway in Escherichia coli, along with EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (pyridoxamine-phosphate oxidase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00069
Structural data: CSA , EC2PDB
Gene Ontology: GO:0048001
UniProtKB/Swiss-Prot: (92) [show] [UniProt]

References

  1. Zhao, G., Pease, A.J., Bharani, N. and Winkler, M.E.
    Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis.
    J. Bacteriol. 177: 2804-2812 (1995). [PMID: 7751290]
  2. Boschi-Muller, S., Azza, S., Pollastro, D., Corbier, C. and Branlant, G.
    Comparative enzymatic properties of GapB-encoded erythrose-4-phosphate dehydrogenase of Escherichia coli and phosphorylating glyceraldehyde-3-phosphate dehydrogenase.
    J. Biol. Chem. 272: 15106-15112 (1997). [PMID: 9182530]
  3. Yang, Y., Zhao, G., Man, T.-K. and Winkler, M.E.
    Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12.
    J. Bacteriol. 180: 4294-4299 (1998). [PMID: 9696782]

[EC 1.2.1.72 created 2006]