EC - 2-oxoisovalerate dehydrogenase (acylating)

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IntEnz Enzyme Nomenclature


Accepted name:
2-oxoisovalerate dehydrogenase (acylating)
Other names:
2-oxoisovalerate dehydrogenase
α-ketoisovalerate dehydrogenase
Systematic name:
3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)



Also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxopentanoate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047101
CAS Registry Number: 37211-61-3


  1. Namba, Y., Yoshizawa, K., Ejima, A., Hayashi, T. and Kaneda, T.
    Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain α-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis.
    J. Biol. Chem. 244: 4437-4447 (1969). [PMID: 4308861]

[EC created 1972]