EC 1.2.1.2 - Formate dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.2.1.2

Names

Accepted name:
formate dehydrogenase
Other names:
FDH I
FDH II
N-FDH
NAD-dependent formate dehydrogenase
NAD-formate dehydrogenase
NAD-linked formate dehydrogenase
formate benzyl-viologen oxidoreductase
formate dehydrogenase (NAD)
formate hydrogenlyase
formate-NAD oxidoreductase
formic acid dehydrogenase
formic hydrogen-lyase
hydrogenlyase
Systematic name:
formate:NAD+ oxidoreductase

Reaction

Cofactors

Comments:

The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [3]. Together with EC 1.12.1.2 hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00063 , PROSITE:PDOC00392
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008863
CAS Registry Number: 9028-85-7
UniProtKB/Swiss-Prot: (37) [show] [UniProt]

References

  1. Davison, D.C.
    Studies on plant formic dehydrogenase.
    Biochem. J. 49: 520-526 (1951). [PMID: 14886318]
  2. Quayle, J.R.
    Formate dehydrogenase.
    Methods Enzymol. 9: 360-364 (1966).
  3. Jollie, D.R. and Lipscomb, J.D.
    Formate dehydrogenase from Methylosinus trichosporium OB3b. Purification and spectroscopic characterization of the cofactors.
    J. Biol. Chem. 266: 21853-21863 (1991). [PMID: 1657982]

[EC 1.2.1.2 created 1961]