EC 1 - Oxidoreductases
EC 1.2 - Acting on the aldehyde or oxo group of donors
EC 1.2.1 - With NAD+ or NADP+ as acceptor
EC 1.2.1.10 - Acetaldehyde dehydrogenase (acetylating)
IntEnz Enzyme Nomenclature
EC 1.2.1.10
Names
ADA
acylating acetaldehyde dehydrogenase
DmpF
Reaction
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23288 [IUBMB]acetaldehydeName origin: UniProt - CHECKED (C)Formula: C2H4O
Charge: 0ChEBI compound status: CHECKED (C)CoAName origin: UniProt - CHECKED (C)Formula: C21H32N7O16P3S
Charge: -4ChEBI compound status: CHECKED (C)NAD+Name origin: UniProt - CHECKED (C)Formula: C21H26N7O14P2
Charge: -1ChEBI compound status: CHECKED (C)<?>acetyl-CoAName origin: UniProt - CHECKED (C)Formula: C23H34N7O17P3S
Charge: -4ChEBI compound status: CHECKED (C)H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)
Comments:
Also acts, more slowly, on glycolaldehyde, propanal and butanal. In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87, propanal dehydrogenase (propanoylating). Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols. NADP+ can replace NAD+ but the rate of reaction is much slower [3].
Links to other databases
References
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The oxidation of acetaldehyde to acetyl coenzyme A.J. Biol. Chem. 202: 873-890 (1953). [PMID: 13061511]
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Purification, properties, and kinetic mechanism of coenzyme A-linked aldehyde dehydrogenase from Clostridium kluyveri.Arch. Biochem. Biophys. 203: 663-675 (1980). [PMID: 7458347]
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Purification and properties of the physically associated meta-cleavage pathway enzymes 4-hydroxy-2-ketovalerate aldolase and aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain CF600.J. Bacteriol. 175: 377-385 (1993). [PMID: 8419288]
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Characterization of an aldolase-dehydrogenase complex that exhibits substrate channeling in the polychlorinated biphenyls degradation pathway.Biochemistry 48: 6551-6558 (2009). [PMID: 19476337]
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Protein-protein interactions and substrate channeling in orthologous and chimeric aldolase-dehydrogenase complexes.Biochemistry 51: 1942-1952 (2012). [PMID: 22316175]
[EC 1.2.1.10 created 1961, modified 2006, modified 2011]