EC - 4-methylphenol dehydrogenase (hydroxylating)

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IntEnz Enzyme Nomenclature


Accepted name:
4-methylphenol dehydrogenase (hydroxylating)
Other names:
p-cresol methylhydroxylase
p-cresol-(acceptor) oxidoreductase (hydroxylating)
4-cresol dehydrogenase (hydroxylating)
Systematic name:
4-methylphenol:acceptor oxidoreductase (methyl-hydroxylating)




A flavocytochrome c (FAD). Phenazine methosulfate can act as acceptor. A quinone methide is probably formed as intermediate. The first hydroxylation forms 4-hydroxybenzyl alcohol; a second hydroxylation converts this into 4-hydroxybenzaldehyde.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018695
CAS Registry Number: 66772-07-4


  1. Hopper, D.J. and Taylor, D.G.
    The purification and properties of p-cresol-(acceptor) oxidoreductase (hydroxylating), a flavocytochrome from Pseudomonas putida.
    Biochem. J. 167: 155-162 (1977). [PMID: 10588247]
  2. McIntire, W., Edmondson, D.E. and Singer, T.P.
    8α-O-Tyrosyl-FAD: a new form of covalently bound flavin from p-cresol methylhydroxylase.
    J. Biol. Chem. 255: 6553-6555 (1980). [PMID: 7391034]

[EC created 1983, modified 2001, modified 2011, modified 2015]