EC - Ribonucleoside-triphosphate reductase

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IntEnz Enzyme Nomenclature


Accepted name:
ribonucleoside-triphosphate reductase
Other names:
2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase
ribonucleotide reductase
Systematic name:
2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase




Requires a cobamide coenzyme.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00665
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008998
CAS Registry Number: 9068-66-0
UniProtKB/Swiss-Prot: (18) [show] [UniProt]


  1. Blakley, R.L.
    Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii.
    J. Biol. Chem. 240: 2173-2180 (1965).
  2. Goulian, M. and Beck, W.S.
    Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii.
    J. Biol. Chem. 241: 4233-4242 (1966). [PMID: 5924645]
  3. Lammers, M. and Follmann, H.
    The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation.
    Struct. Bonding 54: 27-91 (1983).

[EC created 1972]