EC 1.14.99.22 - Ecdysone 20-monooxygenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.14.99.22

Names

Accepted name:
ecdysone 20-monooxygenase
Other names:
α-ecdysone C-20 hydroxylase
ecdysone 20-hydroxylase
Systematic name:
Ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)

Reaction

Cofactor

Comments:

An enzyme from insect fat body or malpighian tubules involving a heme-thiolate protein (P-450). NADPH can act as ultimate hydrogen donor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004501
CAS Registry Number: 55071-97-1
UniProtKB/Swiss-Prot:

References

  1. Johnson, P. and Rees, H.H.
    The mechanism of C-20 hydroxylation of α-ecdysone in the desert locust, Schistocerca gregaria.
    Biochem. J. 168: 513-520 (1977). [PMID: 606249]
  2. Nigg, H.N., Svoboda, J.A., Thompson, M.J., Dutky, S.R., Kaplanis, J.N. and Robbins, W.E.
    Ecdysome 20-hydroxylase from the midgut of the tobacco hornworm (Manduca sexta L.).
    Experientia 32: 438-439 (1976). [PMID: 5286]
  3. Smith, S.L., Bollenbacher, W.E., Cooper, D.Y., Schleyer, H., Wielgus, J.J. and Gilbert, L.I.
    Ecdysone 20-monooxygenase: characterization of an insect cytochrome p-450 dependent steroid hydroxylase.
    Mol. Cell. Endocrinol. 15: 111-133 (1979). [PMID: 488526]

[EC 1.14.99.22 created 1978]