EC 1.14.99.1 - Prostaglandin-endoperoxide synthase

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IntEnz Enzyme Nomenclature
EC 1.14.99.1

Names

Accepted name:
prostaglandin-endoperoxide synthase
Other names:
(PG)H synthase
PG synthetase
fatty acid cyclooxygenase
prostaglandin G/H synthase
prostaglandin endoperoxide synthetase
prostaglandin synthase
prostaglandin synthetase
Systematic name:
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase

Reaction

Comments:

This enzyme acts both as a dioxygenase and as a peroxidase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004666
CAS Registry Number: 9055-65-6
UniProtKB/Swiss-Prot: (17) [show] [UniProt]

References

  1. DeWitt, D.L. and Smith, W.L.
    Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
    Proc. Natl. Acad. Sci. USA 85: 1412-1416 (1988). [PMID: 3125548]
  2. Ohki, S., Ogino, N., Yamamoto, S. and Hayaishi, O.
    Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.
    J. Biol. Chem. 254: 829-836 (1979). [PMID: 104998]

[EC 1.14.99.1 created 1972, modified 1990]