EC 1.14.21.5 - (S)-canadine synthase

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IntEnz Enzyme Nomenclature
EC 1.14.21.5

Names

Accepted name:
(S)-canadine synthase
Other names:
(S)-tetrahydroberberine synthase
(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming)
Systematic name:
(S)-tetrahydrocolumbamine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)

Reaction

Cofactor

Comments:

A heme-thiolate enzyme (P-450) catalysing an oxidative reaction that does not incorporate oxygen into the product. Oxidation of the methoxyphenol group of the alkaloid tetrahydrocolumbamine results in the formation of the methylenedioxy bridge of canadine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047056
CAS Registry Number: 114308-22-4
UniProtKB/Swiss-Prot:

References

  1. Rueffer, M. and Zenk, M.H.
    Canadine synthase from Thalictrum tuberosum cell cultures catalyses the formation of the methylenedioxy bridge in berberine synthesis.
    Phytochemistry 36: 1219-1223 (1994).

[EC 1.14.21.5 created 1999 as EC 1.1.3.36, transferred 2002 to EC 1.14.21.5]