EC 1.14.21.2 - (S)-cheilanthifoline synthase

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IntEnz Enzyme Nomenclature
EC 1.14.21.2

Names

Accepted name:
(S)-cheilanthifoline synthase
Other names:
(S)-scoulerine oxidase (methylenedioxy-bridge-forming) [ambiguous]
(S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming) [ambiguous]
CYP719A14
Systematic name:
(S)-scoulerine,NADPH:oxygen oxidoreductase [(S)-cheilanthifoline-forming]

Reaction

Cofactor

Comments:

A cytochrome P450 (heme-thiolate) enzyme catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid cheilanthifoline by the oxidative ring closure of adjacent phenolic and methoxy groups of scoulerine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047053 , GO:0102632
CAS Registry Number: 138791-27-2
UniProtKB/Swiss-Prot:

References

  1. Bauer, W. and Zenk, M.H.
    Two methylenedioxy bridge-forming cytochrome P-450 dependent enzymes are involved in (S)-stylopine biosynthesis.
    Phytochemistry 30: 2953-2961 (1991).
  2. Diaz Chavez, M. L., Rolf, M., Gesell, A., Kutchan, T. M.
    Characterization of two methylenedioxy bridge-forming cytochrome P450-dependent enzymes of alkaloid formation in the Mexican prickly poppy Argemone mexicana.
    Arch. Biochem. Biophys. 507: 186-193 (2011). [PMID: 21094631]

[EC 1.14.21.2 created 1999 as EC 1.1.3.33, transferred 2002 to EC 1.14.21.2, modified 2016]