EC 1.14.21.1 - (S)-stylopine synthase

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IntEnz Enzyme Nomenclature
EC 1.14.21.1

Names

Accepted name:
(S)-stylopine synthase
Other name:
(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming)
Systematic name:
(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)

Reaction

Cofactor

Comments:

A heme-thiolate enzyme (P-450) catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the second methylenedioxy bridge of the protoberberine alkaloid stylopine from oxidative ring closure of adjacent phenolic and methoxy groups of cheilanthifoline.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047052
CAS Registry Number: 138791-29-4
UniProtKB/Swiss-Prot:

References

  1. Bauer, W. and Zenk, M.H.
    Two methylenedioxy bridge-forming cytochrome P-450 dependent enzymes are involved in (S)-stylopine biosynthesis.
    Phytochemistry 30: 2953-2961 (1991).

[EC 1.14.21.1 created 1999 as EC 1.1.3.32, transferred 2002 to EC 1.14.21.1]