EC 1.14.19.1 - Stearoyl-CoA 9-desaturase

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IntEnz Enzyme Nomenclature
EC 1.14.19.1

Names

Accepted name:
stearoyl-CoA 9-desaturase
Other names:
Δ9-desaturase
acyl-CoA desaturase
fatty acid desaturase
stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase
stearoyl-CoA desaturase
Systematic name:
stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)

Reaction

Cofactor

Comments:

An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00399
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004768
CAS Registry Number: 9014-34-0
UniProtKB/Swiss-Prot: (18) [show] [UniProt]

References

  1. Fulco, A.J. and Bloch, K.
    Cofactor requirements for the formation of Δ9-unsaturated fatty acids in Mycobacterium phlei.
    J. Biol. Chem. 239: 993-997 (1964). [PMID: 14167617]
  2. Oshino, N., Imai, Y. and Sato, R.
    Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes.
    Biochim. Biophys. Acta 128: 13-27 (1966). [PMID: 4382040]
  3. Oshino, N., Imai, Y. and Sato, R.
    A function of cytochrome b5 in fatty acid desaturation by rat liver microsomes.
    J. Biochem. (Tokyo) 69: 155-167 (1971). [PMID: 5543646]
  4. Strittmatter, P., Sputz, L., Corcoran, D., Rogers, M.J., Setlow, B. and Redline, R.
    Purification and properties of rat liver microsomal stearyl coenzyme A desaturase.
    Proc. Natl. Acad. Sci. USA 71: 4565-4569 (1974). [PMID: 4373719]

[EC 1.14.19.1 created 1972 as EC 1.14.99.5, modified 1986, modified 2000, transferred 2000 to EC 1.14.19.1, modified 2003]