EC 1.14.15.4 - Steroid 11β-monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.15.4

Names

Accepted name:
steroid 11β-monooxygenase
Other names:
steroid 11β-hydroxylase
steroid 11β/18-hydroxylase
cytochrome p450 XIB1
Systematic name:
steroid,reduced-adrenodoxin:oxygen oxidoreductase (11β-hydroxylating)

Reaction

Cofactor

Comments:

A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004507
CAS Registry Number: 9029-66-7
UniProtKB/Swiss-Prot: (14) [show] [UniProt]

References

  1. Grant, J.K. and Brownie, A.C.
    The role of fumarate and TPN in steroid enzymic 11β-hydroxylation.
    Biochim. Biophys. Acta 18: 433-434 (1955). [PMID: 13276417]
  2. Hayano, M. and Dorfman, R.I.
    On the mechanism of the C-11β-hydroxylation of steroids.
    J. Biol. Chem. 211: 227-235 (1954). [PMID: 13211659]
  3. Tomkins, G.M., Michael, P.J. and Curran, J.F.
    Studies on the nature of steroid 11-β hydroxylation.
    Biochim. Biophys. Acta 23: 655-656 (1957). [PMID: 13426185]
  4. Yanagibashi, K., Haniu, M., Shively, J.E., Shen, W.H. and Hall, P.
    The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11β-, 18-hydroxylation, and aldehyde synthesis.
    J. Biol. Chem. 261: 3556-3562 (1986). [PMID: 3485096]
  5. Zuidweg, M.H.J.
    Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata.
    Biochim. Biophys. Acta 152: 144-158 (1968). [PMID: 4967077]

[EC 1.14.15.4 created 1961 as EC 1.99.1.7, transferred 1965 to EC 1.14.1.6, transferred 1972 to EC 1.14.15.4, modified 1989, modified 2014]