EC 1.14.13.92 - Phenylacetone monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.13.92

Names

Accepted name:
phenylacetone monooxygenase
Other name:
PAMO
Systematic name:
phenylacetone,NADPH:oxygen oxidoreductase

Reaction

Cofactor

Comments:

A flavoprotein (FAD). NADH cannot replace NADPH as coenzyme. In addition to phenylacetone, which is the best substrate found to date, this Baeyer-Villiger monooxygenase can oxidize other aromatic ketones [1-(4-hydroxyphenyl)propan-2-one, 1-(4-hydroxyphenyl)propan-2-one and 3-phenylbutan-2-one], some alipatic ketones (e.g. dodecan-2-one) and sulfides (e.g. 1-methyl-4-(methylsulfanyl)benzene).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033776
UniProtKB/Swiss-Prot:

References

  1. Malito, E., Alfieri, A., Fraaije, M.W. and Mattevi, A.
    Crystal structure of a Baeyer-Villiger monooxygenase.
    Proc. Natl. Acad. Sci. USA 101: 13157-13162 (2004). [PMID: 15328411]
  2. Fraaije, M.W., Wu, J., Heuts, D.P.H.M., van Hellemond, E.W., Spelberg, J.H.L. and Janssen, D.B.
    Discovery of a thermostable Baeyer-Villiger monooxygenase by genome mining.
    Appl. Microbiol. Biotechnol. 66: 393-400 (2004). [PMID: 15599520]

[EC 1.14.13.92 created 2005]