EC 1.14.13.9 - Kynurenine 3-monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.13.9

Names

Accepted name:
kynurenine 3-monooxygenase
Other names:
L-kynurenine-3-hydroxylase
kynurenine 3-hydroxylase
kynurenine hydroxylase
Systematic name:
L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)

Reaction

Cofactor

Comments:

A flavoprotein (FAD). Formerly EC 1.14.1.2 and 1.99.1.5.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004502
CAS Registry Number: 9029-61-2
UniProtKB/Swiss-Prot: (53) [show] [UniProt]

References

  1. de Castro, F.T., Price, J.M. and Brown, R.R.
    Reduced triphosphopyridinenucleotide requirement for the enzymatic formation of 3-hydroxykynurenine from L-kynurenine.
    J. Am. Chem. Soc. 78: 2904-2905 (1956).
  2. Okamoto, H. and Hayaishi, O.
    Flavin adenine dinucleotide requirement for kynurenine hydroxylase of rat liver mitochondria.
    Biochem. Biophys. Res. Commun. 29: 394-399 (1967). [PMID: 6076241]
  3. Saito, Y., Hayaishi, O. and Rothberg, S.
    Studies on oxygenases: enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine.
    J. Biol. Chem. 229: 921-934 (1957).

[EC 1.14.13.9 created 1961 as EC 1.99.1.5, transferred 1965 to EC 1.14.1.2, transferred 1972 to EC 1.14.13.9]