EC 1.14.13.79 - ent-kaurenoic acid oxidase

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IntEnz Enzyme Nomenclature
EC 1.14.13.79

Names

Accepted name:
ent-kaurenoic acid oxidase
Systematic name:
ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating)

Reactions

Comments:

Requires cytochrome P450. Catalyses three sucessive oxidations of ent-kaurenoic acid. The second step includes a ring-B contraction giving the gibbane skeleton. In Cucurbita maxima, ent-6α,7α-dihydroxykaur-16-en-19-oate is also formed.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
CAS Registry Number: 337507-95-6
UniProtKB/Swiss-Prot:

References

  1. Helliwell, C.A., Chandler, P.M., Poole, A., Dennis, E.S. and Peacock, W.J.
    The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway.
    Proc. Natl. Acad. Sci. USA 98: 2065-2070 (2001). [PMID: 11172076]

[EC 1.14.13.79 created 2002]