EC 1 - Oxidoreductases
EC 1.14 - Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2
EC 1.14.13 - With NADH or NADPH as one donor, and incorporation of one atom of oxygen
EC 1.14.13.75 - Vinorine hydroxylase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.14.13.75
Names
Accepted name:
vinorine hydroxylase
Systematic name:
vinorine,NADPH:oxygen oxidoreductase (21α-hydroxylating)
Reaction
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17257 [IUBMB]+H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)+NADPHName origin: UniProt - CHECKED (C)Formula: C21H26N7O17P3
Charge: -4ChEBI compound status: CHECKED (C)+O2Name origin: UniProt - CHECKED (C)Formula: O2
Charge: 0ChEBI compound status: CHECKED (C)vinorineName origin: UniProt - CHECKED (C)Formula: C21H22N2O2
Charge: 0ChEBI compound status: CHECKED (C)<?>+H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)+NADP+Name origin: UniProt - CHECKED (C)Formula: C21H25N7O17P3
Charge: -3ChEBI compound status: CHECKED (C)
Cofactor
Comments:
A heme-thiolate protein (P-450). Forms a stage in the biosynthesis of the indole alkaloid ajmaline.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00081
Gene Ontology:
GO:0050596
CAS Registry Number:
162875-03-8
References
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Enzymatic biosynthesis of vomilenine, a key intermediate of the ajmaline pathway, catalysed by a novel cytochrome P-450-dependent enzyme from plant cell cultures of Rauwolfia serpentina.Z. Naturforsch. C: Biosci. 50: 45-53 (1995).
[EC 1.14.13.75 created 2002]