EC 1.14.13.75 - Vinorine hydroxylase

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IntEnz Enzyme Nomenclature
EC 1.14.13.75

Names

Accepted name:
vinorine hydroxylase
Systematic name:
vinorine,NADPH:oxygen oxidoreductase (21α-hydroxylating)

Reaction

Cofactor

Comments:

A heme-thiolate protein (P-450). Forms a stage in the biosynthesis of the indole alkaloid ajmaline.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050596
CAS Registry Number: 162875-03-8

References

  1. Falkenhagen, H. and Stöckigt, J.
    Enzymatic biosynthesis of vomilenine, a key intermediate of the ajmaline pathway, catalysed by a novel cytochrome P-450-dependent enzyme from plant cell cultures of Rauwolfia serpentina.
    Z. Naturforsch. C: Biosci. 50: 45-53 (1995).

[EC 1.14.13.75 created 2002]