EC 1.14.13.7 - Phenol 2-monooxygenase (NADPH)

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IntEnz Enzyme Nomenclature
EC 1.14.13.7

Names

Accepted name:
phenol 2-monooxygenase (NADPH)
Other names:
phenol o-hydroxylase
phenol hydroxylase
Systematic name:
phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)

Reaction

Cofactor

Comments:

A flavoprotein (FAD). The enzyme from the fungus Trichosporon cutaneum has a broad substrate specificity, and has been reported to catalyse the hydroxylation of a variety of substituted phenols, such as fluoro-, chloro-, amino- and methyl-phenols and also dihydroxybenzenes. cf. EC 1.14.14.20, phenol 2-monooxygenase (FADH2).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018662
CAS Registry Number: 37256-84-1
UniProtKB/Swiss-Prot: (11) [show] [UniProt]

References

  1. Nakagawa, H. and Takeda, Y.
    Phenol hydroxylase.
    Biochim. Biophys. Acta 62: 423-426 (1962). [PMID: 14478080]
  2. Neujahr, H.Y. and Gaal, A.
    Phenol hydroxylase from yeast. Sulfhydryl groups in phenol hydroxylase from Trichosporon cutaneum.
    Eur. J. Biochem. 35: 386 (1973). [PMID: 4146224]
  3. Neujahr, H.Y. and Gaal, A.
    Phenol hydroxylase from yeast. Sulfhydryl groups in phenol hydroxylase from Trichosporon cutaneum.
    Eur. J. Biochem. 58: 351-357 (1975). [PMID: 810352]

[EC 1.14.13.7 created 1972, modified 2011, modified 2016]