EC - Quinine 3-monooxygenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
quinine 3-monooxygenase
Other name:
quinine 3-hydroxylase
Systematic name:
quinine,NADPH:oxygen oxidoreductase



Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050591


  1. Relling, M.V., Evans, R., Dass, C., Desiderio, D.M. and Nemec, J.
    Human cytochrome P450 metabolism of teniposide and etoposide.
    J. Pharmacol. Exp. Ther. 261: 491-496 (1992). [PMID: 1578365]
  2. Zhang, H., Coville, P.F., Walker, R.J., Miners, J.O., Birkett, D.J. and Wanwimolruk, S.
    Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine.
    Br. J. Clin. Pharmacol. 43: 245-252 (1997). [PMID: 9088578]
  3. Zhao, X.-J., Kawashiro, T. and Ishizaki, T.
    Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.
    Drug Metab. Dispos. 26: 188-191 (1998). [PMID: 9456308]
  4. Zhao, X.-J., Yokoyama, H., Chiba, K., Wanwimolruk, S. and Ishizaki, T.
    Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human liver microsomes and nine recombinant human cytochromes P450.
    J. Pharmacol. Exp. Ther. 279: 1327-1334 (1996). [PMID: 8968357]

[EC created 2000]