EC 1.14.13.53 - 4'-methoxyisoflavone 2'-hydroxylase

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IntEnz Enzyme Nomenclature
EC 1.14.13.53

Names

Accepted name:
4'-methoxyisoflavone 2'-hydroxylase
Other names:
isoflavone 2'-monooxygenase [ambiguous]
isoflavone 2'-hydroxylase [ambiguous]
Systematic name:
formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)

Reaction

Cofactor

Comments:

A heme-thiolate protein (P-450). Acts on isoflavones with a 4'-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC 1.14.13.89, isoflavone 2'-hydroxylase, is less specific and acts on other isoflavones as well as 4'-methoxyisoflavones.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047957
CAS Registry Number: 110183-49-8
UniProtKB/Swiss-Prot:

References

  1. Hinderer, W., Flentje, U. and Barz, W.
    Microsomal isoflavone 2'-hydroxylases and 3'-hydroxylases from chickpea (Cicer arietinum L) cell-suspensions induced for pterocarpan phytoalexin formation.
    FEBS Lett. 214: 101-106 (1987).

[EC 1.14.13.53 created 1992, modified 2005]