EC - Leukotriene-B4 20-monooxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
leukotriene-B4 20-monooxygenase
Other names:
LTB4 20-hydroxylase
LTB4 ω-hydroxylase
leucotriene-B4 ω-hydroxylase
leukotriene-B4 20-hydroxylase
Systematic name:
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)




A heme-thiolate protein (P-450). Not identical with EC, leukotiene-E4 20-monooxygenase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052871 , GO:0050051 , GO:0052870
CAS Registry Number: 90119-11-2


  1. Romano, M.C., Eckardt, R.D., Bender, P.E., Leonard, T.B., Straub, K.M. and Newton, J.F.
    Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases.
    J. Biol. Chem. 262: 1590-1595 (1987). [PMID: 3027095]
  2. Shak, S. and Goldstein, I.M.
    Leukotriene B4 ω-hydroxylase in human polymorphonuclear leukocytes. Partial purification and identification as a cytochrome P-450.
    J. Clin. Invest. 76: 1218-1228 (1985). [PMID: 4044832]
  3. Soberman, R.J., Harper, T.W., Murphy, R.C. and Austen, K.F.
    Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes.
    Proc. Natl. Acad. Sci. USA 82: 2292-2295 (1985). [PMID: 2986111]

[EC created 1989]