EC 1.14.13.152 - Geraniol 8-hydroxylase

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IntEnz Enzyme Nomenclature
EC 1.14.13.152

Names

Accepted name:
geraniol 8-hydroxylase
Other names:
CYP76B6
CYP76B10
G10H
CrG10H
SmG10H
Systematic name:
geraniol,NADPH:oxygen oxidoreductase (8-hydroxylating)

Reaction

Comments:

Requires cytochrome P450. Also hydroxylates nerol and citronellol, cf. EC 1.14.13.151 linalool 8-monooxygenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the product rather than 10-hydroxygeraniol as used by references 1-3. See prenol nomenclature Pr-1. The cloned enzyme also catalysed, but less efficiently, the 3'-hydroxylation of naringenin (cf. EC 1.14.13.21, flavonoid 3'-monooxygenase) [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102811
UniProtKB/Swiss-Prot:

References

  1. Collu, G., Unver, N., Peltenburg-Looman, A. M., van der Heijden, R., Verpoorte, R., Memelink, J.
    Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis.
    FEBS Lett. 508: 215-220 (2001). [PMID: 11718718]
  2. Wang, J., Liu, Y., Cai, Y., Zhang, F., Xia, G., Xiang, F.
    Cloning and functional analysis of geraniol 10-hydroxylase, a cytochrome P450 from Swertia mussotii Franch.
    Biosci. Biotechnol. Biochem. 74: 1583-1590 (2010). [PMID: 20699579]
  3. Sung, P. H., Huang, F. C., Do, Y. Y., Huang, P. L.
    Functional expression of geraniol 10-hydroxylase reveals its dual function in the biosynthesis of terpenoid and phenylpropanoid.
    J. Agric. Food Chem. 59: 4637-4643 (2011). [PMID: 21504162]

[EC 1.14.13.152 created 2012]