EC 1.14.12.18 - Biphenyl 2,3-dioxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.12.18

Names

Accepted name:
biphenyl 2,3-dioxygenase
Other name:
biphenyl dioxygenase
Systematic name:
biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)

Reaction

Cofactor

Comments:

Requires Fe2+. The enzyme from Burkholderia fungorum LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske-type iron-sulfur cluster and a catalytic mononuclear nonheme iron centre. Chlorine-substituted biphenyls can also act as substrates. Similar to the three-component enzyme systems EC 1.14.12.3 (benzene 1,2-dioxygenase) and EC 1.14.12.11 (toluene dioxygenase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00493
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018687
UniProtKB/Swiss-Prot:

References

  1. Haddock, J.D. and Gibson, D.T.
    Purification and characterization of the oxygenase component of biphenyl 2,3-dioxygenase from Pseudomonas sp. strain LB400.
    J. Bacteriol. 177: 5834-5839 (1995). [PMID: 7592331]
  2. Haddock, J.D., Pelletier, D.A. and Gibson, D.T.
    Purification and properties of ferredoxinBPH, a component of biphenyl 2,3-dioxygenase of Pseudomonas sp. strain LB400.
    J. Indust. Microbiol. Biotechnol. 19: 355-359 (1997). [PMID: 9451832]
  3. Broadus, R.M. and Haddock, J.D.
    Purification and characterization of the NADH:ferredoxinBPH oxidoreductase component of biphenyl 2,3-dioxygenase from Pseudomonas sp. strain LB400.
    Arch. Microbiol. 170: 106-112 (1998). [PMID: 9683647]

[EC 1.14.12.18 created 2001]