EC 1.14.11.8 - Trimethyllysine dioxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.11.8

Names

Accepted name:
trimethyllysine dioxygenase
Other names:
TML hydroxylase
TML-α-ketoglutarate dioxygenase
trimethyllysine α-ketoglutarate dioxygenase
TMLD
TML dioxygenase
trimethyllysine,2-oxoglutarate dioxygenase
ε-trimethyllysine 2-oxoglutarate dioxygenase
6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Systematic name:
N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Reaction

Cofactors

Comments:

Requires Fe2+ and ascorbate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050353
CAS Registry Number: 74622-49-4
UniProtKB/Swiss-Prot:

References

  1. Hulse, J.D., Ellis, S.R. and Henderson, L.M.
    Carnitine biosynthesis. β-Hydroxylation of trimethyllysine by an α-ketoglutarate-dependent mitochondrial dioxygenase.
    J. Biol. Chem. 253: 1654-1659 (1978). [PMID: 627563]

[EC 1.14.11.8 created 1983]