EC 1.14.11.27 - [histone H3]-lysine-36 demethylase

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IntEnz Enzyme Nomenclature
EC 1.14.11.27

Names

Accepted name:
[histone H3]-lysine-36 demethylase
Other names:
JHDM1A
JmjC domain-containing histone demethylase 1A
H3-K36-specific demethylase
histone-lysine (H3-K36) demethylase
histone demethylase
protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase
Systematic name:
protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase

Reactions

Cofactor

Comments:

Requires iron(II). Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys-36. Lysine residues exist in three methylation states (mono-, di- and trimethylated). The enzyme preferentially demethylates the dimethyl form of Lys-36 (K36me2), which is its natural substrate, to form the monomethyl and unmethylated forms of Lys-36. It can also demethylate the monomethyl- but not the trimethyl form of Lys-36.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0051864
UniProtKB/Swiss-Prot: (56) [show] [UniProt]

References

  1. Tsukada, Y., Fang, J., Erdjument-Bromage, H., Warren, M.E., Borchers, C.H., Tempst, P. and Zhang, Y.
    Histone demethylation by a family of JmjC domain-containing proteins.
    Nature 439: 811-816 (2006). [PMID: 16362057]

[EC 1.14.11.27 created 2006]