EC 1.13.11.50 - Acetylacetone-cleaving enzyme

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IntEnz Enzyme Nomenclature
EC 1.13.11.50

Names

Accepted name:
acetylacetone-cleaving enzyme
Other names:
Dke1
acetylacetone dioxygenase
diketone cleaving dioxygenase
diketone cleaving enzyme
Systematic name:
acetylacetone:oxygen oxidoreductase

Reaction

Cofactor

Comments:

An Fe(II)-dependent enzyme. Forms the first step in the acetylacetone degradation pathway of Acinetobacter johnsonii. While acetylacetone is by far the best substrate, heptane-3,5-dione, octane-2,4-dione, 2-acetylcyclohexanone and ethyl acetoacetate can also act as substrates.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033752
CAS Registry Number: 524047-53-8
UniProtKB/Swiss-Prot:

References

  1. Straganz, G.D., Glieder, A., Brecker, L., Ribbons, D.W. and Steiner, W.
    Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii.
    Biochem. J. 369: 573-581 (2003). [PMID: 12379146]

[EC 1.13.11.50 created 2003]