EC - Homogentisate 1,2-dioxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
homogentisate 1,2-dioxygenase
Other names:
homogentisate dioxygenase
homogentisate oxidase
homogentisate oxygenase
homogentisic acid oxidase
homogentisic acid oxygenase
homogentisic oxygenase
homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
Systematic name:
homogentisate:oxygen 1,2-oxidoreductase (ring-opening)




Requires Fe2+. Formerly EC and

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004411
CAS Registry Number: 9029-49-6
UniProtKB/Swiss-Prot: (84) [show] [UniProt]


  1. Adachi, K., Iwayama, Y., Tanioka, H. and Takeda, Y.
    Purification and properties of homogentisate oxygenase from Pseudomonas fluorescens.
    Biochim. Biophys. Acta 118: 88-97 (1966). [PMID: 5954067]
  2. Crandall, D.I. and Halikis, D.N.
    Homogentisic acid oxidase. I. Distribution in animal tissues and relation to tyrosine metabolism in rat kidney.
    J. Biol. Chem. 208: 629-638 (1954).
  3. Hayaishi, O.
    Direct oxygenation by O2, oxygenases.
    In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes, 2nd ed. vol. 8, Academic Press, New York, 1963, 353-371
  4. Kita, H., Kamimoto, M., Senoh, S., Adachi, T. and Takeda, Y.
    Cystallization and some properties of 3,4-dihydroxyphenylacetate-2,3-oxygenase.
    Biochem. Biophys. Res. Commun. 18: 66-70 (1965).
  5. Knox, W.E. and Edwards, S.W.
    Homogentisate oxidase of liver.
    J. Biol. Chem. 216: 479-487 (1955).
  6. Ravdin, R.G. and Crandall, D.I.
    The enzymatic conversion of homogentisic acid to 4-fumarylacetoacetic acid.
    J. Biol. Chem. 189: 137-149 (1951).

[EC created 1961 as EC, transferred 1965 to EC, transferred 1972 to EC]