EC 1.13.11.31 - Arachidonate 12-lipoxygenase

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IntEnz Enzyme Nomenclature
EC 1.13.11.31

Names

Accepted name:
arachidonate 12-lipoxygenase
Other names:
12-lipoxygenase
12S-lipoxygenase
12Δ-lipoxygenase
Δ12-lipoxygenase
C-12 lipoxygenase
LTA4 synthase
leukotriene A4 synthase
Systematic name:
arachidonate:oxygen 12-oxidoreductase

Reaction

Cofactor

Comments:

The product is rapidly reduced to the corresponding 12S-hydroxy compound.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00077
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004052
CAS Registry Number: 82391-43-3
UniProtKB/Swiss-Prot: (12) [show] [UniProt]

References

  1. Hamberg, M. and Samuelsson, B.
    Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.
    Proc. Natl. Acad. Sci. USA 71: 3400-3404 (1974). [PMID: 4215079]
  2. Nugteren, D.H.
    Arachidonate lipoxygenase in blood platelets.
    Biochim. Biophys. Acta 380: 299-307 (1975). [PMID: 804329]
  3. Wallach, D.P. and Brown, V.R.
    A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases.
    Biochim. Biophys. Acta 663: 361-372 (1981). [PMID: 6783111]

[EC 1.13.11.31 created 1983]