EC 1.13.11.3 - Protocatechuate 3,4-dioxygenase

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IntEnz Enzyme Nomenclature
EC 1.13.11.3

Names

Accepted name:
protocatechuate 3,4-dioxygenase
Other names:
protocatechuate oxygenase
protocatechuic 3,4-dioxygenase
protocatechuic 3,4-oxygenase
protocatechuic acid oxidase
Systematic name:
protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)

Reaction

Cofactor

Comments:

Requires Fe3+. The enzyme, which participates in the degradation of aromatic compounds, catalyses the intradiol addition of both oxygen atoms from molecular oxygen, resulting in ortho-cleavage of the aromatic ring. The type of cleavage leads to mineralization via the intermediate 3-oxoadipate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00079
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018578
CAS Registry Number: 9029-47-4
UniProtKB/Swiss-Prot:

References

  1. Fujisawa, H. and Hayaishi, O.
    Protocatechuate 3,4-dioxygenase. I. Crystallization and characterization.
    J. Biol. Chem. 243: 2673-2681 (1968). [PMID: 4967959]
  2. Gross, S.R., Gafford, R.D. and Tatum, E.L.
    The metabolism of protocatechuic acid by Neurospora.
    J. Biol. Chem. 219: 781-796 (1956). [PMID: 13319299]
  3. Stanier, R.Y. and Ingraham, J.L.
    Protocatechuic acid oxidase.
    J. Biol. Chem. 210: 799-820 (1954). [PMID: 13211618]

[EC 1.13.11.3 created 1961 as EC 1.99.2.3, transferred 1965 to EC 1.13.1.3, transferred 1972 to EC 1.13.11.3]