EC 1.13.11.2 - Catechol 2,3-dioxygenase

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IntEnz Enzyme Nomenclature
EC 1.13.11.2

Names

Accepted name:
catechol 2,3-dioxygenase
Other names:
2,3-pyrocatechase
catechol 2,3-oxygenase
catechol oxygenase
metapyrocatechase
pyrocatechol 2,3-dioxygenase
cato2ase
xylE (gene name)
Systematic name:
catechol:oxygen 2,3-oxidoreductase (decyclizing)

Reaction

Cofactor

Comments:

Requires FeII. The enzyme initiates the meta-cleavage pathway of catechol degradation.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00078
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018577
CAS Registry Number: 9029-46-3
UniProtKB/Swiss-Prot:

References

  1. Hayaishi, O.
    Direct oxygenation by O2, oxygenases.
    In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes, 2nd ed. vol. 8, Academic Press, New York, 1963, 353-371
  2. Kojima, Y., Itada, N. and Hayaishi, O.
    Metapyrocatechase: a new catechol-cleaving enzyme.
    J. Biol. Chem. 236: 2223-2228 (1961). [PMID: 13757654]
  3. Nozaki, M., Kagamiyama, H. and Hayaishi, O.
    Metapyrocatechase. I. Purification, crystallization and some properties.
    Biochem. Z. 338: 582-590 (1963). [PMID: 14087325]
  4. Nakai, C., Hori, K., Kagamiyama, H., Nakazawa, T., Nozaki, M.
    Purification, subunit structure, and partial amino acid sequence of metapyrocatechase.
    J. Biol. Chem. 258: 2916-2922 (1983). [PMID: 6826545]
  5. Junker, F., Field, J.A., Bangerter, F., Ramsteiner, K., Kohler, H.-P., Joannou, C.L., Mason, J.R., Leisinger, T. and Cook, A.M.
    Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
    Biochem. J. 300: 429-436 (1994). [PMID: 8002948]
  6. Junker, F., Leisinger, T. and Cook, A.M.
    3-Sulphocatechol 2,3-dioxygenase and other dioxygenases (EC 1.13.11.2 and EC 1.14.12.-) in the degradative pathways of 2-aminobenzenesulphonic, benzenesulphonic and 4-toluenesulphonic acids in Alcaligenes sp. strain O-1.
    Microbiology (Reading, Engl.) 140: 1713-1722 (1994). [PMID: 8075807]

[EC 1.13.11.2 created 1965 as EC 1.13.1.2, transferred 1972 to EC 1.13.11.2, modified 1999, modified 2013]