EC 1.13.11.17 - Indole 2,3-dioxygenase

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IntEnz Enzyme Nomenclature
EC 1.13.11.17

Names

Accepted name:
indole 2,3-dioxygenase
Other names:
IDO [ambiguous]
indole oxidase
indole-oxygen 2,3-oxidoreductase (decyclizing)
indole:O2 oxidoreductase
indoleamine 2,3-dioxygenase [ambiguous]
indole:oxygen 2,3-oxidoreductase (decyclizing)
Systematic name:
indole:oxygen 2,3-oxidoreductase (ring-opening)

Reaction

Cofactors

Comments:

Enzymes from the plants Tecoma stans, Jasminum grandiflorum and Zea mays are flavoproteins containing copper. They are part of enzyme systems that form either anthranil (3,4-benzoisoxazole) (Tecoma stans), anthranilate (Jasminum grandiflorum) or both (Zea mays) as the final product. A second enzyme from Tecoma stans is not a flavoprotein, does not require copper, and is part of a system that forms anthranilate as the final product.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047719
CAS Registry Number: 37256-57-8

References

  1. Divakar, N.G., Subramanian, V., Sugumaran, M. and Vaidyanathan, C.S.
    Indole oxygenase from the leaves of Jasminum grandiflorum.
    Plant Sci. Lett. 15: 177-181 (1979).
  2. Kunapuli, S.P. and Vaidyanathan, C.S.
    Purification and characterization of a new indole oxygenase from the leaves of Tecoma stans L.
    Plant Physiol. 71: 19-23 (1983). [PMID: 16662784]
  3. Nair, P.M. and Vaidyanathan, C.S.
    An indole oxidase isolated from the leaves of Tecoma stans.
    Biochim. Biophys. Acta 81: 496-506 (1964). [PMID: 14170321]
  4. Chauhan, Y. S., Rathore, V. S., Garg, G. K., Bhargava, A.
    Detection of an indole oxidizing system in maize leaves.
    Biochem. Biophys. Res. Commun. 83: 1237-1245 (1978). [PMID: 697856]

[EC 1.13.11.17 created 1972, modified 1986]