EC - Hydrogenase (acceptor)

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IntEnz Enzyme Nomenclature


Accepted name:
hydrogenase (acceptor)
Other names:
H2 producing hydrogenase [ambiguous]
hydrogen-lyase [ambiguous]
hydrogenlyase [ambiguous]
uptake hydrogenase [ambiguous]
hydrogen:(acceptor) oxidoreductase
Systematic name:
hydrogen:acceptor oxidoreductase




Uses molecular hydrogen for the reduction of a variety of substances. Contains iron-sulfur clusters. The enzyme from some sources contains nickel.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033748
CAS Registry Number: 9027-05-8
UniProtKB/Swiss-Prot: (35) [show] [UniProt]


  1. Shug, A.L., Wilson, P.W., Green, D.E. and Mahler, H.R.
    The role of molybdenum and flavin in hydrogenase.
    J. Am. Chem. Soc. 76: 3355-3356 (1954).
  2. Adams, M.W.W., Mortenson, L.E. and Chen, J.S.
    Biochim. Biophys. Acta 594: 105-176 (1981).
  3. Vignais, P.M., Billoud, B. and Meyer, J.
    Classification and phylogeny of hydrogenases.
    FEMS Microbiol. Rev. 25: 455-501 (2001). [PMID: 11524134]

[EC created 2002, modified 2003]