EC 1.12.7.2 - Ferredoxin hydrogenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.12.7.2

Names

Accepted name:
ferredoxin hydrogenase
Other names:
H2 oxidizing hydrogenase
H2 producing hydrogenase [ambiguous]
bidirectional hydrogenase
hydrogen-lyase [ambiguous]
hydrogenase (ferredoxin)
hydrogenase I
hydrogenase II
hydrogenlyase [ambiguous]
uptake hydrogenase [ambiguous]
hydrogenase
Systematic name:
hydrogen:ferredoxin oxidoreductase

Reaction

Cofactors

Comments:

Contains iron-sulfur clusters. The enzyme from some sources contains nickel. Can use molecular hydrogen for the reduction of a variety of substances. Formerly EC 1.12.1.1, EC 1.12.7.1, EC 1.98.1.1, EC 1.18.3.1 and EC 1.18.99.1.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00400
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008901
CAS Registry Number: 9080-02-8
UniProtKB/Swiss-Prot:

References

  1. Shug, A.L., Wilson, P.W., Green, D.E. and Mahler, H.R.
    The role of molybdenum and flavin in hydrogenase.
    J. Am. Chem. Soc. 76: 3355-3356 (1954).
  2. Tagawa, K. and Arnon, D.I.
    Ferredoxin as electron carriers in photosynthesis and in the biological production and consumption of hydrogen gas.
    Nature 195: 537-543 (1962).
  3. Valentine, R.C., Mortenson, L.E. and Carnahan, J.E.
    The hydrogenase system of Clostridium pasteurianum.
    J. Biol. Chem. 238: 1141-1144 (1963).
  4. Zumft, W.G. and Mortenson, L.E.
    The nitrogen-fixing complex of bacteria.
    Biochim. Biophys. Acta 416: 1-52 (1975). [PMID: 164247]
  5. Adams, M.W.W.
    The structure and mechanism of iron-hydrogenases.
    Biochim. Biophys. Acta 1020: 115-145 (1990). [PMID: 2173950]
  6. Peters, J.W., Lanzilotta, W.N., Lemon, B.J. and Seefeldt, L.C.
    X-ray crystal structure of the Fe-only hydrogenase (Cpl) from Clostridium pasteurianum to 1.8 Angstrom resolution.
    Science 282: 1853-1858 (1998). [PMID: 9836629]

[EC 1.12.7.2 created 1961 as EC 1.98.1.1, transferred 1965 to EC 1.12.1.1, transferred 1972 to EC 1.12.7.1, transferred 1978 to EC 1.18.3.1, transferred 1984 to EC 1.18.99.1, transferred 2002 to EC 1.12.7.2]