EC - Glutathione peroxidase

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IntEnz Enzyme Nomenclature


Accepted name:
glutathione peroxidase
Other names:
GSH peroxidase
reduced glutathione peroxidase
selenium-glutathione peroxidase
Systematic name:
glutathione:hydrogen-peroxide oxidoreductase




A protein containing a selenocysteine residue. Steroid and lipid hydroperoxides, but not the product of reaction of EC lipoxygenase on phospholipids, can act as acceptor, but more slowly than H2O2 (cf. EC phospholipid-hydroperoxide glutathione peroxidase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00396
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004602
CAS Registry Number: 9013-66-5
UniProtKB/Swiss-Prot: (71) [show] [UniProt]


  1. Chaudiere, J. and Tappel, A.L.
    Purification and characterization of selenium-glutathione peroxidase from hamster liver.
    Arch. Biochem. Biophys. 226: 448-457 (1983). [PMID: 6227287]
  2. Grossmann, A. and Wendel, A.
    Non-reactivity of the selenoenzyme glutathione peroxidase with enzymatically hydroperoxidized phospholipids.
    Eur. J. Biochem. 135: 549-552 (1983). [PMID: 6413205]
  3. Nakamura, W., Hosoda, S. and Hayashi, K.
    Purification and properties of rat liver glutathione peroxidase.
    Biochim. Biophys. Acta 358: 251-261 (1974).

[EC created 1965, modified 1989]