EC 1.11.1.12 - Phospholipid-hydroperoxide glutathione peroxidase

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IntEnz Enzyme Nomenclature
EC 1.11.1.12

Names

Accepted name:
phospholipid-hydroperoxide glutathione peroxidase
Other names:
PHGPX
hydroperoxide glutathione peroxidase
peroxidation-inhibiting protein
peroxidation-inhibiting protein:peroxidase, glutathione (phospholipid hydroperoxide-reducing)
phospholipid hydroperoxide glutathione peroxidase
Systematic name:
glutathione:lipid-hydroperoxide oxidoreductase

Reaction

Cofactor

Comments:

A protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptor; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00396
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047066
CAS Registry Number: 97089-70-8
UniProtKB/Swiss-Prot: (24) [show] [UniProt]

References

  1. Ursini, F., Maiorino, M. and Gregolin, C.
    The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.
    Biochim. Biophys. Acta 839: 62-70 (1985). [PMID: 3978121]
  2. Schnurr, K., Belkner, J., Ursini, F., Schewe, T., Kuhn, H.
    The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.
    J. Biol. Chem. 271: 4653-4658 (1996). [PMID: 8617728]

[EC 1.11.1.12 created 1989, modified 2015]