EC 1.10.3.1 - Catechol oxidase

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IntEnz Enzyme Nomenclature
EC 1.10.3.1

Names

Accepted name:
catechol oxidase
Other names:
o-diphenol oxidoreductase
o-diphenol:oxygen oxidoreductase
o-diphenolase
Dopa oxidase
catecholase
diphenol oxidase
phenolase
polyphenol oxidase
pyrocatechol oxidase
tyrosinase
Systematic name:
1,2-benzenediol:oxygen oxidoreductase

Reaction

Cofactor

Comments:

A type 3 copper protein that catalyses exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. The enzyme also acts on a variety of substituted catechols. It is different from tyrosinase, EC 1.14.18.1, which can catalyse both the monooxygenation of monophenols and the oxidation of catechols.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00398
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004097
CAS Registry Number: 9002-10-2
UniProtKB/Swiss-Prot: (14) [show] [UniProt]

References

  1. Brown, F.C. and Ward, D.N.
    Preparation of a soluble mammalian tyrosinase.
    J. Am. Chem. Soc. 79: 2647-2648 (1957).
  2. Dawson, C.R. and Tarpley, W.B.
    The copper oxidases.
    In: Sumner, J.B. and Myrbäck, K. (Eds.) The Enzymes, 1st ed. vol. 2, Academic Press, New York, 1951, 454-498
  3. Gregory, R.P.F. and Bendall, D.S.
    The purification and some properties of the polyphenol oxidse from tea (Camellia sinensis L.).
    Biochem. J. 101: 569-581 (1966).
  4. Mason, H.S.
    Structures and functions of the phenolase complex.
    Nature 177: 79-81 (1956).
  5. Mayer, A.M. and Harel, E.
    Polyphenol oxidases in plants.
    Phytochemistry 18: 193-215 (1979).
  6. Patil, S.S. and Zucker, M.
    Potato phenolases. Purification and properties.
    J. Biol. Chem. 240: 3938-3943 (1965). [PMID: 5842066]
  7. Pomerantz, S.H.
    3,4-Dihydroxy-L-phenylalanine as the tyrosinase cofactor. Occurrence in melanoma and binding constant.
    J. Biol. Chem. 242: 5308-5314 (1967). [PMID: 4965136]
  8. Robb, D.A.
    Tyrosinase.
    In: Lontie, R. (Ed.) Copper Proteins and Copper Enzymes vol. 2, CRC Press, Boca Raton, FL, 1984, 207-240

[EC 1.10.3.1 created 1961, deleted 1972, reinstated 1978]