EC 188.8.131.52 - Choline dehydrogenase
IntEnz Enzyme Nomenclature
choline-cytochrome c reductase
17433 [IUBMB]AAName origin: UniProt - CHECKED (C)Formula: R
Charge: 0ChEBI compound status: CHECKED (C)cholinecholineName origin: UniProt - CHECKED (C)Formula: C5H14NO
Charge: 1ChEBI compound status: CHECKED (C)<?>AH2AH2Name origin: UniProt - CHECKED (C)Formula: H2R
Charge: 0ChEBI compound status: CHECKED (C)
A quinoprotein. In many bacteria, plants and animals, the osmoprotectant betaine is synthesized using different enzymes to catalyse the conversion of (1) choline into betaine aldehyde and (2) betaine aldehyde into betaine. In plants, the first reaction is catalysed by EC 184.108.40.206, choline monooxygenase, whereas in animals and many bacteria, it is catalysed by either membrane-bound choline dehydrogenase (EC 220.127.116.11) or soluble choline oxidase (EC 18.104.22.168) . The enzyme involved in the second step, EC 22.214.171.124, betaine-aldehyde dehydrogenase, appears to be the same in plants, animals and bacteria.
Links to other databases
Mammalian choline dehydrogenase is a quinoprotein.Agric. Biol. Chem. 49: 3623-3626 (1985).
Preparation and partial purification of soluble choline dehydrogenase from liver mitochondria.Biochem. J. 60: 644-646 (1955). [PMID: 13249959]
Cloning, expression, and purification of choline dehydrogenase from the moderate halophile Halomonas elongata.Appl. Environ. Microbiol. 69: 2126-2132 (2003). [PMID: 12676692]
Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica.J. Biol. Chem. 278: 4932-4942 (2003). [PMID: 12466265]
[EC 126.96.36.199 created 1961, modified 1989, modified 2005]