EC 1.1.1.96 - Diiodophenylpyruvate reductase

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IntEnz Enzyme Nomenclature
EC 1.1.1.96

Names

Accepted name:
diiodophenylpyruvate reductase
Other names:
2-oxo acid reductase
KAR
aromatic α-keto acid
Systematic name:
3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase

Reaction

Comments:

Substrates contain an aromatic ring with a pyruvate side chain. The most active substrates are halogenated derivatives. Compounds with hydroxy or amino groups in the 3 or 5 position are inactive.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047860
CAS Registry Number: 37250-31-0
UniProtKB/Swiss-Prot:

References

  1. Zannoni, V.G. and Weber, W.W.
    Isolation and properties of aromatic α-keto acid reductase.
    J. Biol. Chem. 241: 1340-1344 (1966). [PMID: 5935348]

[EC 1.1.1.96 created 1972]