IntEnz

EC 1.1.1.76 - (S,S)-butanediol dehydrogenase

IntEnz Enzyme Nomenclature
EC 1.1.1.76

Names

Reaction

• 12184 [IUBMB]
  (S,S)-butane-2,3-diol

  (S,S)-butane-2,3-diol

  Name origin: UniProt - CHECKED (C)

  CHEBI:16812

  Formula: C4H10O2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NAD⁺

  NAD(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:57540

  Formula: C21H26N7O14P2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

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  (S)-acetoin

  (S)-acetoin

  Name origin: UniProt - CHECKED (C)

  CHEBI:15687

  Formula: C4H8O2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  NADH

  NADH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57945

  Formula: C21H27N7O14P2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

This enzyme catalyses the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol. It can also catalyse the irreversible reduction of diacetyl to (S)-acetoin.

Links to other databases

References

1. Taylor, M.B. and Juni, E.
   Stereoisomeric specificities of 2,3-butanediol dehydrogenases.
   Biochim. Biophys. Acta 39: 448-457 (1960). [PMID: 13837186]
2. Carballo, J., Martin, R., Bernardo, A., Gonzalez, J.
   Purification, characterization and some properties of diacetyl(acetoin) reductase from Enterobacter aerogenes.
   Eur. J. Biochem. 198: 327-332 (1991). [PMID: 2040298]
3. Takusagawa, Y., Otagiri, M., Ui, S., Ohtsuki, T., Mimura, A., Ohkuma, M., Kudo, T.
   Purification and characterization of L-2,3-butanediol dehydrogenase of Brevibacterium saccharolyticum C-1012 expressed in Escherichia coli.
   Biosci. Biotechnol. Biochem. 65: 1876-1878 (2001). [PMID: 11577733]

[EC 1.1.1.76 created 1972, modified 2010]