EC 1.1.1.64 - Testosterone 17β-dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature
EC 1.1.1.64

Names

Accepted name:
testosterone 17β-dehydrogenase (NADP+)
Other names:
17-ketoreductase
NADP-dependent testosterone-17β-oxidoreductase
Systematic name:
17β-hydroxysteroid:NADP+ 17-oxidoreductase

Reaction

Comments:

Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047045
CAS Registry Number: 9028-63-1
UniProtKB/Swiss-Prot:

References

  1. Endahl, G.L., Kochakian, C.D. and Hamm, D.
    Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine-specific 17β-hydroxy (testosterone) dehydrogenase of guinea pig liver.
    J. Biol. Chem. 235: 2792-2796 (1960). [PMID: 13696735]
  2. Sweat, M.L., Samuels, L.T. and Lumry, R.
    Preparation and characterisation of the enzyme which converts testosterone to androstendione.
    J. Biol. Chem. 185: 75-84 (1950). [PMID: 15436478]
  3. Villee, C.A. and Spencer, J.M.
    Some properties of the pyridine nucleotide-specific 17β-hydroxy steroid dehydrogenase of guinea pig liver.
    J. Biol. Chem. 235: 3615-3619 (1960). [PMID: 13781425]

[EC 1.1.1.64 created 1965]