EC - 3-hydroxyacyl-CoA dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
3-hydroxyacyl-CoA dehydrogenase
Other names:
1-specific DPN-linked β-hydroxybutyric dehydrogenase
3-L-hydroxyacyl-CoA dehydrogenase
3-hydroxyacetyl-coenzyme A dehydrogenase
3-hydroxyacyl coenzyme A dehydrogenase
3-hydroxybutyryl-CoA dehydrogenase
3-hydroxyisobutyryl-CoA dehydrogenase
3-keto reductase
3β-hydroxyacyl coenzyme A dehydrogenase
β-hydroxy acid dehydrogenase
β-hydroxyacyl CoA dehydrogenase
β-hydroxyacyl dehydrogenase
β-hydroxyacyl-coenzyme A synthetase
β-hydroxyacylcoenzyme A dehydrogenase
β-hydroxybutyrylcoenzyme A dehydrogenase
β-ketoacyl-CoA reductase
L-3-hydroxyacyl CoA dehydrogenase
L-3-hydroxyacyl coenzyme A dehydrogenase
Systematic name:
(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase



Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3-hydroxyacyl-hydrolipoate. Some enzymes act, more slowly, with NADP+. Broad specificity to acyl chain-length (cf. EC [long-chain-3-hydroxyacyl-CoA dehydrogenase]).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00060 , PROSITE:PDOC00065
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003857
CAS Registry Number: 9028-40-4
UniProtKB/Swiss-Prot: (240) [show] [UniProt]


  1. Hillmer, P. and Gottschalk, G.
    Solubilization and partial characterisation of particulate dehydrogenases from Clostridium kluyveri.
    Biochim. Biophys. Acta 334: 12-23 (1974).
  2. Lehninger, A.L. and Greville, G.D.
    The enzymatic oxidation of d- and l-β-hydroxybutyrate of particulate dehyrogenases from Clostridium kluyvei.
    Biochim. Biophys. Acta 12: 188-202 (1953). [PMID: 13115428]
  3. Stern, J.R.
    Crystalline β-hydroxybutyrate dehydrogenase from pig heart.
    Biochim. Biophys. Acta 26: 448-449 (1957). [PMID: 13499396]
  4. Wakil, S.J., Green, D.E., Mii, S. and Mahler, H.R.
    Studies on the fatty acid oxidizing system of animal tissues. VI. β-Hydroxyacyl coenzyme A dehydrogenase.
    J. Biol. Chem. 207: 631-638 (1954). [PMID: 13163047]

[EC created 1961]