EC 1.1.1.3 - Homoserine dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.1.1.3

Names

Accepted name:
homoserine dehydrogenase
Other names:
HSD
HSDH
Systematic name:
L-homoserine:NAD(P)+ oxidoreductase

Reactions

Comments:

The yeast enzyme acts most rapidly with NAD+; the Neurospora enzyme with NADP+. The enzyme from Escherichia coli is a multi-functional protein, which also catalyses the reaction of EC 2.7.2.4 (aspartate kinase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00800
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004412
CAS Registry Number: 9028-13-1
UniProtKB/Swiss-Prot: (30) [show] [UniProt]

References

  1. Black, S. and Wright, N.G.
    Homoserine dehydrogenase.
    J. Biol. Chem. 213: 51-60 (1955).
  2. Starnes, W.L., Munk, P., Maul, S.B., Cunningham, G.N., Cox, D.J. and Shive, W.
    Threonine-sensitive aspartokinase-homoserine dehydrogenase complex, amino acid composition, molecular weight, and subunit composition of the complex.
    Biochemistry 11: 677-687 (1972). [PMID: 4551091]
  3. Véron, M., Falcoz-Kelly, F. and Cohen, G.N.
    The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. The two catalytic activities are carried by two independent regions of the polypeptide chain.
    Eur. J. Biochem. 28: 520-527 (1972). [PMID: 4562990]

[EC 1.1.1.3 created 1961, modified 1976]