EC 1.1.1.291 - 2-hydroxymethylglutarate dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.1.1.291

Names

Accepted name:
2-hydroxymethylglutarate dehydrogenase
Other name:
HgD
Systematic name:
(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase

Reaction

Comments:

NADP+ cannot replace NAD+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 3.5.2.18 (enamidase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Δ-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00697
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043718
UniProtKB/Swiss-Prot:

References

  1. Alhapel, A., Darley, D.J., Wagener, N., Eckel, E., Elsner, N. and Pierik, A.J.
    Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
    Proc. Natl. Acad. Sci. USA 103: 12341-12346 (2006). [PMID: 16894175]

[EC 1.1.1.291 created 2006]