EC 1.1.1.270 - 3β-hydroxysteroid 3-dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.1.1.270

Names

Accepted name:
3β-hydroxysteroid 3-dehydrogenase
Other names:
3-KSR
3-keto-steroid reductase
HSD17B7 (gene name)
ERG27 (gene name)
Systematic name:
3β-hydroxysteroid:NADP+ 3-oxidoreductase

Reactions

Comments:

The enzyme acts on multiple 3β-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17β-estradiol 17-dehydrogenase [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0000253
CAS Registry Number: 42616-29-5
UniProtKB/Swiss-Prot: (11) [show] [UniProt]

References

  1. Swindell, A.C. and Gaylor, J.L.
    Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.
    J. Biol. Chem. 243: 5546-5555 (1968). [PMID: 4387005]
  2. Billheimer, J.T., Alcorn, M. and Gaylor, J.L.
    Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis. Purification and properties of 3-β-hydroxysteroid dehydrogenase and Δ5-3-ketosteroid isomerase from bovine corpora lutea.
    Arch. Biochem. Biophys. 211: 430-438 (1981). [PMID: 6946726]
  3. Gachotte, D., Sen, S. E., Eckstein, J., Barbuch, R., Krieger, M., Ray, B. D., Bard, M.
    Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
    Proc. Natl. Acad. Sci. U.S.A. 96: 12655-12660 (1999). [PMID: 10535978]
  4. Marijanovic, Z., Laubner, D., Moller, G., Gege, C., Husen, B., Adamski, J., Breitling, R.
    Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
    Mol. Endocrinol. 17: 1715-1725 (2003). [PMID: 12829805]

[EC 1.1.1.270 created 2002, modified 2012]