EC - Histidinol dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
histidinol dehydrogenase
Other name:
L-histidinol dehydrogenase
Systematic name:
L-histidinol:NAD+ oxidoreductase



Also oxidizes L-histidinal. The Neurospora enzyme also catalyses the reactions of EC (phosphoribosyl-AMP cyclohydrolase) and EC (phosphoribosyl-ATP diphosphatase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00534
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004399
CAS Registry Number: 9028-27-7
UniProtKB/Swiss-Prot: (230) [show] [UniProt]


  1. Adams, E.
    Enzymatic synthesis of histidine from histidinol.
    J. Biol. Chem. 209: 829-846 (1954).
  2. Adams, E.
    L-Histidinal, a biosynthetic precursor of histidine.
    J. Biol. Chem. 217: 325-344 (1955).
  3. Loper, J.C.
    Histidinol dehydrogenase from Salmonella typhimurium. Crystallization and composition studies.
    J. Biol. Chem. 243: 3264-3272 (1968). [PMID: 4872177]
  4. Yourno, J. and Ino, I.
    Purification and crystallization of histidinol dehydrogenase from Salmonella typhimurium LT-2.
    J. Biol. Chem. 243: 3273-3276 (1968). [PMID: 4872176]

[EC created 1961]